Ingredient Information

Wavi is proud to have high quality ingredients at effective dosages. Below you'll find information regarding what we use, why we use it, and how much is in our product.

L-Tyrosine: 2,000mg

High stress environments cause a decrease in critical cognitive processes specifically working memory and recall (Luethi et al., 2008). This is linked to a depletion of catecholamines as a response to stress. L-tyrosine is an amino acid that acts as a precursor to catecholamines like dopamine, epinephrine and norepinephrine. Tyrosine supplementation has been proven to improve task switching and cognitive flexibility through dopaminergic pathways (Steenbergen et al., 2015), and is an effective cognitive enhancer when stress has caused a state of neurotransmitter depletion (Jongkees et al., 2015).

In another study, L-tyrosine was shown to decrease the cognitive performance deficit induced by sleep deprivation (Neri et al., 1995).

The value in L-tyrosine is being able to perform in high stress environments when success is imperative, without falling victim to the effects of stress. 

nooLVL® (Inositol-Enhanced Bonded Arginine Silicate): 1,600mg

nooLVL® stimulates endothelial cells to produce more nitric oxide synthase, which is the enzyme responsible for synthesizing nitric oxide from arginine. This process leads to an increase in nitric oxide levels in the blood vessels, resulting in vasodilation and improved blood flow. nooLVL® binds inositol with arginine making it more bioavailable, offering synergistic benefits across various physiological processes, including improved bioavailability, enhanced NO production, neurotransmitter regulation, cellular signaling, muscle health, and neuroprotection.

Research conducted by Tartar et al. (2019) revealed that individuals who supplemented with nooLvl®  experienced significant improvements in cognitive performance, including enhanced processing speed, working memory, and cognitive flexibility, compared to those taking a placebo. Additionally, participants reported mood enhancements such as reduced fatigue and increased feelings of energy and alertness. Importantly, the study highlighted the safety and tolerability of nooLvl®, indicating its suitability for daily supplementation. 

Alpha-GPC: 500mg

Alpha-GPC, also known as alpha-glycerophosphorylcholine, offers several cognitive and physiological benefits. Research indicates that Alpha-GPC supplementation can increase choline levels in the brain (Gatti et al., 1992), leading to enhanced synthesis of acetylcholine, a neurotransmitter crucial for cognitive functions such as memory and learning. Additionally, increases in choline levels exhibit neuroprotective effects by promoting the production of phospholipids, which help maintain cell membrane integrity and support overall brain health (McGlade et al., 2015). 

Alpha-GPC also contribute to enhanced physiological performance. Ziegenfuss et al., (2008) proved Alpha-GPC supplementation to enhance exercise performance by increasing growth hormone response and peak force production during resistance exercise. Research done by Bellar et al. (2015), found that Alpha-GPC supplementation can improve isometric strength, enhance hormonal response, and increase muscular endurance, particularly in individuals involved in resistance training.

Beet Root Powder (beta vulgaris): 200mg 

Beet root powder has proven benefits in health and performance due to its rich nitrate content. Supplementation has proven to enhance exercise performance, endurance, and oxygen delivery to muscles, as demonstrated in studies by Jones et al. (2018). Additionally, beetroot powder has been shown to help lower blood pressure and improve cardiovascular health markers, such as reduced inflammation and enhanced endothelial function, as evidenced in studies examining the effects of nitrate supplementation in chronic obstructive pulmonary disease patients (Berry et al., 2016).

Beetroot powder provides antioxidant and anti-inflammatory properties that protect cells from oxidative stress and inflammation (Chen et al., 2021). Emerging research also suggests potential benefits for cognitive function, including improved cognitive performance and cerebral blood flow (Wightman et al., 2015). Incorporating beetroot powder into your daily routine can support exercise performance, cardiovascular health, antioxidant defense, and cognitive function naturally.

Gingko Biloba extract (leaf): 120mg

Ginkgo biloba has been shown to offer various benefits. A study by Tan et al. (2015), found that Ginkgo biloba extract can stabilize cognitive function and memory in elderly individuals. Its active compounds, such as flavonoids and terpenoids, contribute to enhanced cerebral blood flow and support neuronal health (Mahadevan & Park, 2008). Studies have demonstrated Ginkgo biloba's potential in reducing symptoms of age-related cognitive decline and enhancing memory and concentration (Mix & Crews, 2002). Ginkgo biloba has been associated with improved circulation, which can benefit cardiovascular health and peripheral circulation (Singh et al., 2018).

 Caffeine (Green Tea Extract, leaf): 75mg

The benefits of caffeine on performance are well known throughout the performance and health and wellness communities. Where synthetic caffeine lacks in benefit outside of stimulation, caffeine derived from green tea extract contains polyphenols, particularly catechins, that possess potent antioxidant properties (Higdon & Frei, 2003). These antioxidants help counteract oxidative stress and inflammation in the body, potentially offering superior cellular protection compared to synthetic caffeine alone. 

Overconsumption of caffeine can harm the cardiovascular system, and has been proven to have a dose-response relationship to a decrease in cerebral blood flow (Turnbull et al., 2017). With cerebral blood flow being one of Wavi Compete's greatest desired outcomes, we've opted to provide enough caffeine for stimulation without decreasing the efficacy of our more valued ingredients. 

Most energy drinks and pre-workouts on the market have anywhere between 200-300mg of caffeine per dose. With 75mg of caffeine per dose, our customers will ingest just under the amount of caffeine than a cup of coffee, allowing them to consume other sources of caffeine with lower risk of overconsumption. 

L-Theanine: 75mg

An amino acid commonly found in green tea, L-Theanine can help reduce stress in both mind and body. In a study conducted by Kimura et al. (2007), participants took L-Theanine before a stressful task and experienced lower heart rate and stress hormone levels when compared to placebo. This suggests that L-Theanine may calm the nervous system by reducing the activation of stress-related pathways in the brain. 

A study conducted by Haskell et al. (2008), observed the effects of L-Theanine on its own and combined with caffeine to see its effects on mood and cognitive performance. L-Theanine alone caused headaches and slightly worsened numeric working memory. Caffeine alone improved reaction time and reduced mental fatigue. When combined, they boosted accuracy in memory tasks, sped up reaction times, and improved alertness while reducing headaches and tiredness. Owen et al. (2008), came to a similar conclusion, with a dose as low as 50mg of caffeine with 100mg of L-Theanine, found improved task switching and reduced distraction with supplementation.

We've added L-Theanine along with caffeine to drive stimulation without the negative side effects, and improve cognitive performance in a smoother conscious state. 

 Saffron Extract 2% saffranal, (Crocus Sativus, flower): 15mg

Saffron extract, derived from the Crocus sativus flower, is a substance with growing attention from researchers for its potential mood-enhancing and cognitive benefits. In a study conducted by Moghadam et al. (2021), two groups of participants completed resistance training sessions, with one group supplementing saffron while the other took a placebo. After six weeks, those taking saffron showed increased levels of mood-related substances like dopamine and serotonin. Happiness levels increased more in the saffron group compared to the placebo group. Both groups showed improvements in muscular endurance, with the saffron group showing greater improvements.

An additional study conducted by Jackson et al. (2021), investigated the effects of taking saffron extract on mood in healthy adults with mild feelings of low mood, anxiety, or stress. Participants supplemented with saffron extract or a placebo for 8 weeks. The saffron group reported feeling less depressed and having better social relationships. Levels of crocetin, a compound in saffron, increased with supplementation and were linked to improvements in depression and mood. Additionally, saffron helped maintain heart rate variability during stress, suggesting it may increase resilience to stress-related issues. Overall, saffron extract may help improve mood and resilience in healthy individuals with mild mood disturbances.

The high performance world is filled with stressors, often leading to feelings of anxiety, being overwhelmed, and decreased feelings of happiness. We opted to include saffranal in our blend to help high performing individuals manage feelings of anxiety, improve mood, and minimize negative responses to stress. 

Huperzine-A: 95 mcg

Huperzine-A (HupA), is widely studied for the treatment of Alzheimer's due to its neuroprotective effects. A study conducted by Friedli & Inestrosa (2021), demonstrated that HupA works by inhibiting acetylcholinesterase, an enzyme that breaks down acetylcholine, which is critical in working memory. HupA also reduces the buildup of harmful proteins like beta-amyloid and activates pathways that promote neuronal survival and plasticity. Additionally, it helps regulate inflammation and preserves mitochondrial function in the brain.

Wavi uses HupA to work synergistically with our other ingredients that increase acetylcholine levels, by ensuring those levels are maintained for a longer time by inhibiting the breakdown of acetylcholine.

Important Notes

Considerations in taking any supplement is that individuals may respond differently to all supplementation protocols. Results may vary between individuals, and consumption should be adjusted according to response. 

References

  1. Bellar, D., LeBlanc, N. R., & Campbell, B. (2015). The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength. Journal of the International Society of Sports Nutrition, 12, 42. https://doi.org/10.1186/s12970-015-0103-x
  2. Berry, M. J., Justus, N. W., Hauser, J. I., Case, A. H., Helms, C. C., Basu, S., Rogers, Z., Lewis, M. T., & Miller, G. D. (2015). Dietary nitrate supplementation improves exercise performance and decreases blood pressure in COPD patients. Nitric Oxide: Biology and Chemistry, 48, 22–30. https://doi.org/10.1016/j.niox.2014.10.007
  3. Chen, L., Zhu, Y., Hu, Z., Wu, S., & Jin, C. (2021). Beetroot as a functional food with huge health benefits: Antioxidant, antitumor, physical function, and chronic metabolomics activity. Food Science & Nutrition, 9(11), 6406–6420. https://doi.org/10.1002/fsn3.2577
  4. Friedli, M. J., & Inestrosa, N. C. (2021). Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease. Molecules, 26(21), Article 21. https://doi.org/10.3390/molecules26216531
  5. Gatti, G., Barzaghi, N., Acuto, G., Abbiati, G., Fossati, T., & Perucca, E. (1992). A comparative study of free plasma choline levels following intramuscular administration of L-alpha-glycerylphosphorylcholine and citicoline in normal volunteers. International Journal of Clinical Pharmacology, Therapy, and Toxicology, 30(9), 331–335.
  6. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., & Scholey, A. B. (2008). The effects of L-theanine, caffeine and their combination on cognition and mood. Biological Psychology, 77(2), 113–122. https://doi.org/10.1016/j.biopsycho.2007.09.008
  7. Higdon, J. V., & Frei, B. (2003). Tea catechins and polyphenols: Health effects, metabolism, and antioxidant functions. Critical Reviews in Food Science and Nutrition, 43(1), 89–143. https://doi.org/10.1080/10408690390826464
  8. Jackson, P. A., Forster, J., Khan, J., Pouchieu, C., Dubreuil, S., Gaudout, D., Moras, B., Pourtau, L., Joffre, F., Vaysse, C., Bertrand, K., Abrous, H., Vauzour, D., Brossaud, J., Corcuff, J. B., Capuron, L., & Kennedy, D. O. (2021). Effects of Saffron Extract Supplementation on Mood, Well-Being, and Response to a Psychosocial Stressor in Healthy Adults: A Randomized, Double-Blind, Parallel Group, Clinical Trial. Frontiers in Nutrition, 7, 606124. https://doi.org/10.3389/fnut.2020.606124
  9. Jones, A. M., Thompson, C., Wylie, L. J., & Vanhatalo, A. (2018). Dietary Nitrate and Physical Performance. Annual Review of Nutrition, 38, 303–328. https://doi.org/10.1146/annurev-nutr-082117-051622
  10. Jongkees, B. J., Hommel, B., Kühn, S., & Colzato, L. S. (2015). Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands—A review. Journal of Psychiatric Research, 70, 50–57. https://doi.org/10.1016/j.jpsychires.2015.08.014
  11. Kimura, K., Ozeki, M., Juneja, L. R., & Ohira, H. (2007). L-Theanine reduces psychological and physiological stress responses. Biological Psychology, 74(1), 39–45. https://doi.org/10.1016/j.biopsycho.2006.06.006
  12. Luethi, M., Meier, B., & Sandi, C. (2008). Stress effects on working memory, explicit memory, and implicit memory for neutral and emotional stimuli in healthy men. Frontiers in Behavioral Neuroscience, 2, 5. https://doi.org/10.3389/neuro.08.005.2008
  13. Mahadevan, S., & Park, Y. (2008). Multifaceted therapeutic benefits of Ginkgo biloba L.: Chemistry, efficacy, safety, and uses. Journal of Food Science, 73(1), R14-19. https://doi.org/10.1111/j.1750-3841.2007.00597.x
  14. McGlade, E., Agoston, A. M., DiMuzio, J., Kizaki, M., Nakazaki, E., Kamiya, T., & Yurgelun-Todd, D. (2019). The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males. Journal of Attention Disorders, 23(2), 121–134. https://doi.org/10.1177/1087054715593633
  15. Mix, J. A., & Crews, W. D. (2002). A double-blind, placebo-controlled, randomized trial of Ginkgo biloba extract EGb 761 in a sample of cognitively intact older adults: Neuropsychological findings. Human Psychopharmacology, 17(6), 267–277. https://doi.org/10.1002/hup.412
  16. Moghadam, B. H., Bagheri, R., Roozbeh, B., Ashtary-Larky, D., Gaeini, A. A., Dutheil, F., & Wong, A. (2021). Impact of saffron (Crocus Sativus Linn) supplementation and resistance training on markers implicated in depression and happiness levels in untrained young males. Physiology & Behavior, 233, 113352. https://doi.org/10.1016/j.physbeh.2021.113352
  17. Neri, D. F., Wiegmann, D., Stanny, R. R., Shappell, S. A., McCardie, A., & McKay, D. L. (1995). The effects of tyrosine on cognitive performance during extended wakefulness. Aviation, Space, and Environmental Medicine, 66(4), 313–319.
  18. Owen, G. N., Parnell, H., De Bruin, E. A., & Rycroft, J. A. (2008). The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutritional Neuroscience, 11(4), 193–198. https://doi.org/10.1179/147683008X301513
  19. Singh, S. K., Srivastav, S., Castellani, R. J., Plascencia-Villa, G., & Perry, G. (2019). Neuroprotective and Antioxidant Effect of Ginkgo biloba Extract Against AD and Other Neurological Disorders. Neurotherapeutics, 16(3), 666–674. https://doi.org/10.1007/s13311-019-00767-8
  20. Steenbergen, L., Sellaro, R., Hommel, B., & Colzato, L. S. (2015). Tyrosine promotes cognitive flexibility: Evidence from proactive vs. reactive control during task switching performance. Neuropsychologia, 69, 50–55. https://doi.org/10.1016/j.neuropsychologia.2015.01.022
  21. Tan, M.-S., Yu, J.-T., Tan, C.-C., Wang, H.-F., Meng, X.-F., Wang, C., Jiang, T., Zhu, X.-C., & Tan, L. (2015). Efficacy and adverse effects of ginkgo biloba for cognitive impairment and dementia: A systematic review and meta-analysis. Journal of Alzheimer’s Disease: JAD, 43(2), 589–603. https://doi.org/10.3233/JAD-140837
  22. Tartar, J. L., Kalman, D., & Hewlings, S. (2019). A Prospective Study Evaluating the Effects of a Nutritional Supplement Intervention on Cognition, Mood States, and Mental Performance in Video Gamers. Nutrients, 11(10), 2326. https://doi.org/10.3390/nu11102326
  23. Turnbull, D., Rodricks, J. V., Mariano, G. F., & Chowdhury, F. (2017). Caffeine and cardiovascular health. Regulatory Toxicology and Pharmacology: RTP, 89, 165–185. https://doi.org/10.1016/j.yrtph.2017.07.025
  24. Wightman, E. L., Haskell-Ramsay, C. F., Thompson, K. G., Blackwell, J. R., Winyard, P. G., Forster, J., Jones, A. M., & Kennedy, D. O. (2015). Dietary nitrate modulates cerebral blood flow parameters and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation. Physiology & Behavior, 149, 149–158. https://doi.org/10.1016/j.physbeh.2015.05.035
  25. Ziegenfuss, T., Landis, J., & Hofheins, J. (2008). Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise. Journal of the International Society of Sports Nutrition, 5(1), P15. https://doi.org/10.1186/1550-2783-5-S1-P15